The 20-year-old Mbappe fired home his league-leading 19th goal of the campaign with 17 minutes remaining.
The big-hitting 39-year-old opener, who has scored 9,727 runs in 284 ODIs, is set to play his first international since last July against England on Wednesday.
A swathe of elite cyclists have chosen this five-day race, won by Valverde last year, as part of their early-season bid to get back to top form.
Athletics South Africa has pledged its "unqualified support" for Semenya and she has received support from other sports.
The opening round of the 2019 FIA World Cup for Cross-Country Rallies takes place in Qatar from February 21 to 26.
Monfils, the runner-up three years ago, held off Wawrinka's second-set surge to ease through the decider.