Gharafa came from behind to hand Rayyan a 2-1 defeat.
AS Roma, also among the competition favourites, drew Lyon which could be the clash of the round.
The Italian's position has come under intense scrutiny this season during a slump that has left the Foxes just a point above the relegation zone.
The academy will have seven football pitches and the capacity to enrol 1,000 children between six and 18 years old.
No matter what happens, 2022 will leave a lasting legacy because it is the first World Cup to be organised in the Middle East.
Muaither's hopes of staying in the top flight suffered a big jolt when Umm Salal handed them a 1-0 defeat.
Speculation over the experienced forward's future has intensified in recent weeks.
The 32-year-old has been sidelined since Arsenal's 6-0 Champions League group win against Ludogorets on October 19.
Juventus edge close to last eight after defeating Porto 2-0.
Real remain top on 52 points, one ahead of nearest challengers Barcelona and three clear of Sevilla in third, and still have one game in hand on both of their title rivals.
The only negatives in a comfortable win for United were injuries to Mkhitaryan and midfielder Michael Carrick.
The stadium in Al Thumama is located in one of the most rapidly developing areas of Doha.
Striker Baghdad Bounedjah slams in five goals as Al Sadd rout Al Arabi and regain the top position.