Head coach Jacco Verhaeren said he was encouraged by the quick times produced during Australian trials over the past six days, setting them up for another fierce battle with arch-rivals the United States.
The 18-year-old, seen as Ledecky's biggest challenger at the worlds in South Korea next month, dipped under the magical four-minute mark to clock 3:59.35 and secure her place on the team.
Lithuania's swimming federation said earlier this month that Meilutyte faced a suspension of up to two years for missing three drug tests, meaning she would be ruled out of the 2020 Tokyo Olympics.
A fan favourite in China because of his ability and looks, Ning won the 100m free world title in 2015 and was a four-time gold medallist at the Asian Games a year earlier.
Ana, the overall winner of FINA Marathon Swim World Series in 2010, 2012, 2014 and 2018, clocked 2:03:51.5 and won the exciting women’s race, which ended in a close finish.
Japan’s 18-year-old swimming sensation and Tokyo2020 medal hopeful Rikako Ikee was diagnosed with leukaemia.
QSA President delighted with huge participation and enthusiasm of young swimmers.
The Doha Open Water Challenge, open to the public, will be organised on the sidelines of a high-profile FINA/HOSA Marathon Swim World Series Doha (QAT) 2019.
Franklin has won five Olympic gold medals and six overall plus 11 world titles in her career.
The Americans won 17 gold medals, with Russia, the nearest challengers, winning six.
FINA made the announcement on Thursday saying that the event will consist of a three-leg competition between March and May and include the Olympic and world champions, as well as world-record holders and top-ranked swimmers.
The 24-year-old Seto pipped his more famous rival by only 0.08sec to make a piece of history on the first day of action in the Chinese city of Hangzhou.
Italy's anti-doping agency (Nado) had demanded an eight-year ban for the 2005 and 2007 world champion.
Lochte's decision to pursue treatment follows an incident in California where police were called on Thursday morning after he tried to break into his own hotel room.
The Swede sets new World Cup mark in 50m butterfly.