The win gives the Pacers a 2-1 lead in the first-round clash and they can take a stranglehold on the series with a win on Sunday in Indianapolis.
Head coach Popovich did not attend Thursday's game which took place just a day after the passing of his wife Erin Popovich who died from a long-term illness.
Philadelphia 76ers crushed Miami Heat 128-108 to grab a 2-1 lead in their first-round playoff series.
James scored 20 of his 46 points in the opening quarter, getting off to a torrid start in which he singlehandedly outscored the Pacers 13-0
DeMar DeRozan scored 37 points as Raptors took a 2-0 lead against Washington Wizards in their best-of-seven Eastern Conference NBA playoff series.
Golden State made 15 of 31 attempts from three-point range, contrasting sharply with San Antonio, who could only muster four from 28 attempts.
Victor Oladipo scored a game-high 32 points to power the Indiana Pacers over the host Cavaliers 98-80 on Sunday in the opening game of their first-round NBA playoff series.
Klay Thompson scored a game-high 27 points on 11-of-13 shooting, including 5-of-6 from 3-point range, and Kevin Durant added 24 points, eight rebounds and seven assists to power Golden State.
The Warriors served a stern warning that they will not be easily dethroned despite Stephen Curry's knee injury.
The league announced Meeks had tested positive for banned substances ipamorelin and growth hormone releasing peptide-2.
More than 22 million fans bought tickets for games throughout the year, with the figure of 22,124,559 eclipsing the previous record of 21,997,412 set in 2016-2017.
Markelle Fultz of Philadelphia 76ers became the youngest player in NBA history with a triple-double, with 13 points, 10 assists and 10 rebounds.
Golden State Warriors brought their regular season campaign to a close with a tame defeat to Utah Jazz.
Thunder were joined in the playoffs by the San Antonio Spurs, who beat Sacramento Kings to seal their 21st consecutive appearance in the postseason
Philadelphia are now assured of at least a top-four finish in the East